Article ID Journal Published Year Pages File Type
2485154 Journal of Pharmaceutical Sciences 2012 9 Pages PDF
Abstract
Relationship between two polymorphs is described to be either enantiotropic or monotropic with transition temperature/transition point (Tt) below the melting point (Tm) of the lower melting form in former case and above the Tm of the higher melting form in latter case. In the present work, a new methodology for assessing thermodynamic Tt of two polymorphs has been developed. Configurational free energy (Gc) of amorphous with respect to each polymorph was calculated to determine the Tt. This method was used to determine the Tt and polymorphic relationship of two model drugs, namely, carbamazepine and nateglinide. This method was also compared with the previous methodologies. Deduced Tt of carbamazepine using this methodology was compared with previously reported values and was found to be in good agreement. A monotropic relationship was established between nateglinide polymorphs based on Tt obtained by present methodology and previous reported methodologies. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1843-1851, 2012
Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery
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