Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2485301 | Journal of Pharmaceutical Sciences | 2011 | 18 Pages |
Abstract
Prediction of human clearance plays a critical role in early drug discovery and development. However, there is no consensus on the most appropriate method to gather such data. A variety of in vivo and in vitro methods exist and a comparison of in vitro data from a standard set of compounds has been called for. This paper compares the predictive capacity of human liver microsomes and singleâspecies scaling (SSS) from rat and nonâhuman primate for a standard set of compounds representing marketed drugs. The results enable a framework to be proposed wherein compounds are selected using in vitro methods alone or in vitro methods combined with SSS in the rat. Further investigation of this framework has the potential to increase the efficiency of drug discovery and reduce animal use. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:4518-4535, 2011
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Kevin Beaumont, Iain Gardner, Kathryn Chapman, Michael Hall, Malcolm Rowland,