Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2485444 | Journal of Pharmaceutical Sciences | 2013 | 10 Pages |
Abstract
Octreotide (OCT) was recently found to have a high binding affinity for the somatostatin receptor expressed on tumor cells. In this study, OCT-polyethylene glycol-stearic acid (OCT-Phe-PEG-A) was used as a targeting molecule for NâoctylâO, Nâcarboxymethyl chitosan (OCC) micelles loaded with doxorubicin (DOX). For in vivo fluorescence imaging, the fluorescent probe Cyanine 7 (Cy7) was successfully loaded into OCC micelles with or without OCT modification (Cy7-OCC, Cy7-OCC-OCT), and their physicochemical properties were compared with DOXâloaded micelles (DOX-OCC and DOX-OCC-OCT). All micelles were less than 120Â nm with spherical shape and zeta potential of around â30Â mV. Enhanced tumorâtargeting capacity of OCC-OCT micelles was observed in BALB/c nude mice bearing MCFâ7 cancer xenografts as compared with the OCC micelles. Moreover, pharmacodynamic studies demonstrated that DOX-OCC-OCT presented a strongest inhibition of tumor growth and lowest systemic toxicity compared with the DOX solution and DOX-OCC micelles. All the results indicated that OCC-OCT micelles might be a promising tumorâtargeting carrier for cancer therapy.
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Authors
Aifeng Zou, Yan Chen, Meirong Huo, Jing Wang, Yong Zhang, Jianping Zhou, Qiang Zhang,