Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2485453 | Journal of Pharmaceutical Sciences | 2013 | 12 Pages |
Abstract
The objective of this work was to develop a modified release system for the local anesthetic lidocaine (LDC), using poly(εâcaprolactone) (PCL) nanospheres (NSs), to improve the pharmacological properties of the drug when administered by the infiltration route. In vitro experiments were used to characterize the system and investigate the release mechanism. The NSs presented a polydispersion index of 0.072, an average diameter of 449.6ânm, a zeta potential of â20.1âmV, and an association efficiency of 93.3%. The release profiles showed that the release of associated LDC was slower than that of the free drug. Atomic force microscopy analyses showed that the spherical structure of the particles was preserved as a function of time, as well as after the release experiments. Cytotoxicity and pharmacological tests confirmed that association with the NSs reduced the toxicity of LDC, and prolonged its anesthetic action. This new formulation could potentially be used in applications requiring gradual anesthetic release, especially dental procedures.
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Estefânia Vangelie Ramos Campos, Nathalie Ferreira Silva de Melo, Viviane Aparecida Guilherme, Eneida de Paula, André Henrique Rosa, Daniele Ribeiro de Araújo, Leonardo Fernandes Fraceto,