Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2485510 | Journal of Pharmaceutical Sciences | 2008 | 10 Pages |
Abstract
Biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been studied extensively for the controlled release of peptide and protein drugs. In addition to polymer biodegradation, chemical degradation of the incorporated peptide/protein has also been reported in PLGA devices, and the role of the polymer in promoting these reactions has been debated. This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed.
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Authors
M.L. Houchin, E.M. Topp,