Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2485676 | Journal of Pharmaceutical Sciences | 2008 | 12 Pages |
Abstract
Darcy's law and Fick's law of Part I are combined with bulk and species conservation of mass equations, respectively, to obtain flow and transport models for swelling drug delivery systems. The model identifies three distinct regimes and makes the appropriate simplifying assumptions for each. The result is a set of highly nonlinear, coupled, integroâpartial differential equations. The advantage of this model is that it can be easily modified to account for multiple simplified scenarios and geometries. As an example, boundary conditions are given for a radially symmetric drug delivery device.
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Tessa F. Weinstein, Lynn S. Bennethum, John H. Cushman,