Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2485907 | Journal of Pharmaceutical Sciences | 2010 | 11 Pages |
Abstract
The present work reports on the development of waterâinâoil (w/o) emulsions for the intravesical administration of 5âaminolevulinic acid (ALA). The physicochemical properties of droplet size, zeta potential, and viscosity of the emulsions are characterized and the ability of the emulsions to release ALA following in vitro application is tested. The delivery systems are administered intravesically for 1 and 3âh in rats to examine the drug accumulation in bladder tissue. The mean size and zeta potential of the emulsions are 50-200ânm and â3 to â14âmV, respectively. The loading of ALA into the emulsions resulted in a slower and sustained release. The release extent was found to be inversely related to the droplet size of the emulsions. The emulsions did not increase the drug permeation into tissues during short exposure duration (1âh). When the dwell time was extended to 3âh, the systems showed a 2.7âfold increase in the ALA concentration in the bladder wall. Images of confocal laser scanning microscopy demonstrated a higher and deeper fluorescence signal, with emulsion administration, as compared to the aqueous control. Intravesical emulsion delivery provides a significant advantage for drugs targeting bladder tissues. © 2009 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 99: 2375-2385, 2010
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
JiaâYou Fang, PaoâChu Wu, ChiaâLang Fang, ChaoâHuang Chen,