Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2486032 | Journal of Pharmaceutical Sciences | 2010 | 9 Pages |
Abstract
The star-shaped poly(lactide-co-glycolide (PLGA)-β-cyclodextrin (PLGA-β-CD) copolymer was synthesized by reacting L-lactide, glycolide, and β-cyclodextrin in the presence of stannous octoate as a catalyst. The structure of PLGA-β-CD copolymer was confirmed with 1H-NMR, 13C-NMR, and FT-IR spectra. Adriamycin (ADR), which is an antitumor antibiotic, was encapsulated within micro- and nanoparticles made of PLGA-β-CD with a modified double emulsion method. Relatively low amount of β-CD and catalyst were used in order to obtain high molecular weight polymers. Differential scanning calorimetry (DSC) was used to determine the thermal properties of star-shaped copolymers. The reduction of interactions between the starshaped polyester molecules is due to their branched structure lowered Tg and Tm compared to linear PLGA copolymers. Effects of the experimental parameters, such as copolymer composition, ADR concentration, copolymer concentration, and poly(vinyl alcohol) concentration, on particular size and encapsulation efficiency were investigated. An increase in the internal aqueous phase volume led to a decrease in particles average size. A decrease in the polymer concentration resulted in increasing the particle average size from 135.5 to 325.6 nm. The high entrapment efficiency (EE) (about 65%) was obtained for 220 μm particles. All of the release profiles indicated a close relationship between each formulation variable and the amount of ADR released.
Keywords
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Authors
Mohammad Mooguee, Yadollah Omidi, Soodabeh Davaran,