Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2486085 | Journal of Pharmaceutical Sciences | 2010 | 8 Pages |
Abstract
In this article we show the possibility to form amorphous αâglucose/βâglucose molecular alloys directly in the solid state by comilling crystalline αâglucose and crystalline βâglucose. Contrary to the usual melt quenching process, milling does not induce any mutarotation so that alloys can be obtained for the whole range of anomeric concentration. This offers the unique possibility to explore the phase diagram of this binary system which appears to be a eutectic mixture. The structural and thermodynamic investigations have been performed by powder Xâray diffraction and differential scanning calorimetry. © 2009 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1476-1483, 2010
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
N. Dujardin, J.F. Willart, E. Dudognon, F. Danède, M. Descamps,