| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2486115 | Journal of Pharmaceutical Sciences | 2007 | 9 Pages |
Abstract
The release of chlorhexidine diacetate (CX) from a selfâcuring polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CXâPEM/THFM drug release system. Xâray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96:2048-2056, 2007
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Authors
K. Gong, M. Braden, M.P. Patel, I.U. Rehman, Z. Zhang, J.A. Darr,