| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2486119 | Journal of Pharmaceutical Sciences | 2007 | 4 Pages |
Abstract
The isothermal crystallization of glycine in a 40/60 (w/w) sucrose/glycine excipient system is examined with the goal of comparing the kinetic information obtained by using the Johnson-Mehl-Avrami (JMA) equation with that collected using a novel, dispersive kinetic model equation recently proposed by the author. It is found that while both models explain the experimental data reasonably well, the latter equation fits the data, collected at temperatures in the range 241-251 K, without the use of empirical parameters. The values of the activation energy and Arrhenius constant (frequency factor) for both models agree within experimental error. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96:2107-2110, 2007
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Authors
Peter J. Skrdla,