| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2486148 | Journal of Pharmaceutical Sciences | 2011 | 6 Pages |
Abstract
A practical timeâsaving method of determination of equilibrium blood-plasma concentration ratio is described. The method is based on the analysis of compound plasma concentrations in regular blood sample and the blood sample diluted with blank plasma. Since only plasma concentrations are analyzed, the method can be conveniently applied in routine pharmacokinetic studies with minimal additional work for obtaining blood-plasma ratio. The method can also be easily used in in vitro experiment. The results obtained by suggested method are in good agreement with that obtained by common in vitro measurements of blood-plasma ratio.
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Authors
Leonid M. Berezhkovskiy, Xiaolin Zhang, Jonathan Cheong,