| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2486306 | Journal of Pharmaceutical Sciences | 2006 | 10 Pages |
Abstract
The in vitro dissolution of carbamazepine (CBZ) was investigated using an automated artificial stomach-duodenum (ASD) model. Successful simulation of the dog physiology in the fasted state showed that the rank order of the ASD estimated bioavailabilities is as follows: Form IIIÂ >Â Form IÂ >Â dihydrate. This result is in excellent agreement with those found in literature. Additional simulations comparing different gastric transit times during fasted and fed states are also discussed. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association
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Authors
Stephen R. Carino, David C. Sperry, Michael Hawley,