Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2486332 | Journal of Pharmaceutical Sciences | 2011 | 7 Pages |
Abstract
The potential of intranasally administered carnosic acid to enhance the endogenous levels of neurotrophins [nerve growth factor and brainâderived neurotrophic factor] in the brain was investigated. Hydroxypropylâβâcyclodextrin (HPâβâCD) was used to enhance the aqueous solubility of carnosic acid. The effect of different concentrations of chitosan on the permeation of carnosic acid was investigated across the bovine olfactory mucosa using Franz diffusion cell setup. The formulations were administered [intranasal (i.n.)/subcutaneous route] in Sprague-Dawley rats, and the neurotrophins were sampled from the brain by microdialysis after the treatment period and measured by enzymeâlinked immunosorbent assay. Phase solubility studies revealed that the solubility of carnosic acid was enhanced significantly with increase in the concentration of HPâβâCD. The neurotrophin levels were enhanced significantly upon i.n. administration of carnosic acid with chitosan, which was approximately 1.5-2âfold more over the parenteral route. Noseâtoâbrain delivery of carnosic acid along with chitosan is a potential approach for treating disorders associated with depletion of neurotrophins. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:3139-3145, 2011
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Authors
Siva Ram Kiran Vaka, S. Narasimha Murthy, Michael A. Repka, Tamas Nagy,