Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2486340 | Journal of Pharmaceutical Sciences | 2011 | 12 Pages |
Abstract
Nitrofurantoin (NF) drug is known to transform to a hydrate form in aqueous medium. The hydration stability and dissolution rate of a few cocrystals of NF were compared with that of its stable β polymorph and hydrate form II. Hydrogen bonding and molecular packing in the novel cocrystal structures were analyzed. Pharmaceutical cocrystals of NF with pâaminobenzoic acid (PABA) and urea showed superior physicochemical properties compared with the known lâarginine salt hydrate. All the solidâstate adducts were characterized by singleâcrystal Xâray diffraction, Xâray powder diffraction, differential scanning calorimetry, and thermogravimetric analysis. NF-PABA cocrystal was found to be superior among the compounds studied in terms of minimal transformation to NF hydrate and comparable dissolution rate to the reference drug. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:3233-3244, 2011
Keywords
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Suryanarayan Cherukuvada, N. Jagadeesh Babu, Ashwini Nangia,