Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2486357 | Journal of Pharmaceutical Sciences | 2011 | 10 Pages |
Abstract
Ordered mesoporous silica (OMS) materials are considered a promising drug delivery system for the dissolution enhancement of poorly soluble compounds. The purpose of the present work was to determine structural and behavioral changes of compressed OMS material necessary for the development of an immediateârelease oralâdosage formulation. Two types of OMS materials (SBAâ15 and COKâ12) were subjected to pressures both in and beyond the tabletting region and characterized by nitrogen physisorption, scanning and transmission electron microscopy, smallâangle Xâray scattering, and differential scanning calorimetry. Itraconazole was used as the poorly soluble model drug and the release process with respect to pressure was determined in vitro. The resulting decreased drug release due to increased pressure was recovered by incorporating a plastically deforming material such as microcrystalline cellulose in combination with croscarmellose sodium. These findings further elucidate the understanding of their structural behavior for the advancement as a drug delivery carrier. © 2011 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 100:3411-3420, 2011
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Monica Vialpando, Alexander Aerts, Jeroen Persoons, Johan Martens, Guy Van Den Mooter,