Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2486433 | Journal of Pharmaceutical Sciences | 2011 | 9 Pages |
Abstract
The solid-state properties of antiprotozoal ternidazole (3-(2-methyl-5-nitroimidazol-1-yl)-propan-1-ol) have been studied. Crystals are triclinic in the temperature interval between 100 and 333 K (melting point) with two different molecular conformations present in the asymmetric unit (Zâ²Â = 2) and two of each conformer make up a tetramer held together by hydrogen bonding. Its melting enthalpy at 333 K is 25.65 (±1.29) kJ·molâ1. Linear plots were obtained for the melting temperature versus pressure (dP/dT = 5.67 (±0.08) MPa·Kâ1] and the glass transition versus pressure [dP/dT = 7.73 (±1.76) MPa·Kâ1]. No crystalline polymorphism could be detected; thus, the single-crystal structure that has been found is most likely the stable one.
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Authors
Nathalie Mahé, Marc-Antoine Perrin, Maria Barrio, Béatrice Nicolaï, Ivo B. Rietveld, Josep-LluÃs Tamarit, René Céolin,