Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2486591 | Journal of Pharmaceutical Sciences | 2009 | 8 Pages |
Abstract
Nanocarriers have been developed aiming at drug delivery; however, the irritating effects of these nanoparticles on naïve or inflamed articular tissues are not known. Poly(D,L-lactide) (N-PLA), methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (N-PEG-PLA), and Dynasan 116 (SLN) were used to prepare the nanocarriers. The average diameter (nm) and zeta potential (mV) of these particles were, respectively, 251 and â33.2, 169 and â22.1, and 105 and â13.0. Naive or carrageenan-primed knee-joints received 100 µL of nanoparticle suspensions or control solution. Incapacitation and articular diameter were determined hourly. Synovial leukocytes were counted 6 h after nanoparticle injection. N-PLA increased the articular diameter and leukocytes, but did not cause incapacitation. In primed knee-joints, N-PLA caused incapacitation, and increased the articular diameter and leukocytes. SLN did not produce inflammatory signals either in naive or primed knees. In primed knee-joints, N-PEG-PLA presented an intermediate effect characterized by an increase in the articular diameter, and a slight increase of leukocytes, but not incapacitation. These results suggest that solid lipid nanoparticles may be safer than polymeric ones, which may be correlated to their chemical composition and superficial charge. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:4844-4851, 2009
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Authors
Tatiany Jovita de Faria, Eduardo Souza-Silva, Daniel Teixeira de Oliveira, Elenara Lemos Senna, Carlos Rogério Tonussi,