Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2486647 | Journal of Pharmaceutical Sciences | 2011 | 7 Pages |
Abstract
New data sets on both (i) equilibrium theophylline (TH) partitioning/binding in stratum corneum and (ii) transient TH diffusion through human epidermis are explained by an extended partition-diffusion model with reversible binding. Data conform to a linear binding isotherm within the tested concentration range (0-2000 μg/mL) with an equilibrium ratio of bound-to-free solute of approximately 1.4. The permeability coefficient for TH is 4.86 Ã 10â5 cm/h, and the lag time is 20.1 h. Binding occurs as a slow process, significantly affecting the kinetics of dermal penetration. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:2989-2995, 2011
Keywords
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Authors
H. Frederick Frasch, Ana M. Barbero, Justin M. Hettick, Johannes M. Nitsche,