Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2486862 | Journal of Pharmaceutical Sciences | 2008 | 5 Pages |
Abstract
It has been shown previously that it is impossible to measure the volume of distribution at steady state conclusively for a multicompartment system from an iv bolus dose only. The problem lies in deciding from which compartment elimination of the drug occurs in the compartmental model. In this paper a new modelling strategy is examined whereby the compartment of elimination may be identified uniquely for the case of two-compartment models. The two models examined predict different profiles in the absorption phase of an oral profile. An in vivo data set is provided that favours a peripheral elimination explanation of its observed pharmacokinetics, based on the 'goodness of fit'.
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Authors
J.W.T. Yates, P.A. Arundel,