Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487106 | Journal of Pharmaceutical Sciences | 2009 | 9 Pages |
Abstract
The objective of the study was to use the combined approach of gamma scintigraphy and pharmacokinetics, in order to understand the mechanisms explaining the pharmacokinetic differences observed for a modified release (MR) formulation, when administered either in the fed or fasted state. Ten healthy subjects were recruited into a randomized three period single dose study, each subject receiving UK-294,315 40Â mg IR (fasted), 100Â mg MR (fasted) or 100Â mg MR (after a high fat meal). Cmax values were markedly higher for the MR tablet in the fed state versus fasted and mean residence time was about 3Â h longer for fasted versus fed; there was little difference in apparent oral clearance. In the fasted state, average gastric emptying of the intact tablet occurred at 1.2Â h postdose, with gastric emptying of intact tablet observed in all subjects. In the fed state, rapid disintegration of the MR tablet was observed by scintigraphy, with 7/9 subjects showing complete disintegration in the stomach. Complete disintegration occurred 10.1Â h postdose in the fasted state versus 5.9Â h after a high fat meal. The study showed that in the fed state, the MR tablet eroded more rapidly than in the fasted state, leading to an overall increase in the rate of absorption.
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Authors
J. Davis, J. Burton, A.L. Connor, R. Macrae, I.R. Wilding,