Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487329 | Journal of Pharmaceutical Sciences | 2008 | 16 Pages |
Abstract
We describe a novel integrated approach to the study of polymorphic transformation that includes quasiâisothermal modulated temperature differential scanning calorimetry (QIâMTDSC) and microthermal analysis (MTA), with a view to studying the thermal, kinetic and spatial characteristics of the process. Form II and I caffeine was prepared and conventional DSC and hot stage microscopy performed. The Form II to I transition at circa 413 K was associated with a change in crystal habit to needle shaped crystals. QIâMTDSC was used to measure the heat capacity of the system as a function of temperature, while MTA was able to spatially differentiate between the two polymorphs in compressed systems. We present a novel extension of the reduced temperature method whereby we apply it for the first time to linear rising temperature data corresponding to the transition; the analysis suggests a close approximation to Arrhenius behavior. We also describe a heat transfer model that allows calculation of the thermal gradients within a hermetically sealed pan for the first time. The combined approach has therefore allowed the characterization of the thermodynamics and kinetics of the transformation process as well as spatial identification of the distribution of the transformation in compressed systems. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 97:1285-1300, 2008
Keywords
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Authors
Radhesh Manduva, Vicky L. Kett, Simon R. Banks, John Wood, Mike Reading, Duncan Q.M. Craig,