Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487414 | Journal of Pharmaceutical Sciences | 2008 | 9 Pages |
Abstract
A pure orthorhombic phase sample of D(-)-salicin was purified and characterized for calorimetric measurements. From differential scanning calorimetry (DSC) measurements it was found that the onset and maximum temperatures of the fusion peak were Tonâ=â(473.30â±â0.05) K and Tmaxâ=â(474.74â±â0.05) K, respectively, and that the corresponding standard enthalpy of fusion was ÎcrlHm°â=â(55.5â±â0.4) kJâmolâ1. From the last two values the standard entropy of fusion is calculated as ÎcrlSm°â=â(116.9â±â0.4) Jâmolâ1âKâ1. The standard molar enthalpy of formation of orthorhombic D(-)-salicin at Tâ=â298.15 K, was determined as ÎfHm°(C13H18O7, cr, orthorhombic)â=ââ(1366.9â±â3.2) kJâmolâ1, by combustion calorimetry. From the results of solution calorimetry obtained in this work and some auxiliary values taken from the literature the enthalpy of reaction of hydrolysis of D(-)-salicin to produce β-glucose and o-hydroxybenzyl alcohol was found marginally thermoneutral, if the uncertainty interval was considered. Additionally, specific heat capacity measurements on the orthorhombic phase, glass and liquid-quenched glass obtained by DSC was reported. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:5354-5362, 2008
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Authors
Susana S. Pinto, HermÃnio P. Diogo,