Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487466 | Journal of Pharmaceutical Sciences | 2008 | 33 Pages |
Abstract
The joint cavity constitutes a discrete anatomical compartment that allows for local drug action after intraâarticular injection. Drug delivery systems providing local prolonged drug action are warranted in the management of postoperative pain and not least arthritic disorders such as osteoarthritis. The present review surveys various themes related to the accomplishment of the correct timing of the events leading to optimal drug action in the joint space over a desired time period. This includes a brief account on (patho)physiological conditions and novel potential drug targets (and their location within the synovial space). Particular emphasis is paid to (i) the potential feasibility of various depot formulation principles for the intraâarticular route of administration including their manufacture, drug release characteristics and in vivo fate, and (ii) how release, mass transfer and equilibrium processes may affect the intraâarticular residence time and concentration of the active species at the ultimate receptor site.
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Claus Larsen, Jesper Ãstergaard, Susan W. Larsen, Henrik Jensen, Stine Jacobsen, Casper Lindegaard, Pia H. Andersen,