The Confusion of Indexing Aspirin Crystals

Much of the existing literature dealing with crystalline aspirin is vague or ambiguous with regard to indexing of the crystal faces. The inconsistency with which the indices of the dominant faces have been assigned leads to confusion in analysis of surface properties. To clarify this, we have conducted crystal growth experiments on aspirin, and indexed the crystal faces with X‐ray diffraction (XRD), paying special attention to the placement of symmetry elements. The space group was confirmed as P21/c, and the dominant face was (100). Contact angle measurements made on the two major faces of aspirin indicate the (100) face to be more hydrophobic than the (001) face, likely due to the acetyloxy moiety, not the carboxyl, exposed on the (100). © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:1361-1367, 2008