Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487568 | Journal of Pharmaceutical Sciences | 2007 | 11 Pages |
Abstract
Complex tablets with zeroâorder drug release characteristics were fabricated using threeâdimensional printing processes. The matrix tablets exhibited material gradients in radial direction and had drugâfree releaseâbarrier layers on both bases. The content of model drug acetaminophen incorporated in the tablets through premixing reached up to 68% of the tablets' weight. Tablets with ethylcellulose gradients showed acceptable mechanical and pharmacotechnical properties, as indicated by crushing strength, friability, and content uniformity tests. The structure and the gradients of ethylcellulose in the tablets were envisaged through environmental scanning electron microscopy and fluorescence tracing technique. Erosion and dissolution studies in vitro indicated that drug was released via a twoâdimensional surface erosion mechanism, and 98% of the drug could be released linearly in 12 h. Tablets with other releaseâretardation material gradients such as sodium lauryl sulfate, stearic acid, and Eudragit RSâ100 showed similar releaseâretardation effects by different releaseâretardation mechanisms. Through the printing of releaseâretardation materials, 3DP processes could easily prepare tablets with high dosage and special design features for furnishing the desired drug release characteristics. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2446-2456, 2007
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Deng Guang Yu, Xiang Liang Yang, Wei Dong Huang, Jie Liu, Yun Gan Wang, Huibi Xu,