Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487631 | Journal of Pharmaceutical Sciences | 2007 | 8 Pages |
Abstract
The crystal structures of the analgesic compounds anhydrous naloxone and naltrexone hydrochloride were determined ab initio from high resolution laboratory Xâray powder diffraction data. Both compounds crystallize in the orthorhombic space group P212121 with lattice parameters of a = 14.6588(10) Ã
, b = 17.4363(9) Ã
, c = 7.96200(22) Ã
, and V = 2035.06(23) Ã
3 for naloxone hydrochloride and a = 15.4560(5) Ã
, b = 14.9809(4) Ã
, c = 7.84121(18) Ã
, and V = 1815.58(11) Ã
3 for naltrexone hydrochloride. The crystal structure of anhydrous naloxone hydrochloride forms oneâdimensional chains through hydrogen bonds. In the crystal structure of anhydrous naltrexone hydrochloride, twoâdimensional sheets are formed by hydrogen bonds. The dehydration processes of naloxone hydrochloride dehydrate and naltrexone hydrochloride tetrahydrate was analyzed by DTA, DSC, TG, and MG. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 3316-3323, 2007
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Authors
Kunihisa Sugimoto, Robert E. Dinnebier, Marek Zakrzewski,