Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487643 | Journal of Pharmaceutical Sciences | 2007 | 4 Pages |
Abstract
Published data on the concentration dependence of osmotic pressure of solutions of bovine serum albumin in 0.15Â M NaCl at concentrations up to greater than 400 g/L are shown to be described to within experimental uncertainty by a simple oneâparameter model in which protein molecules are represented by effective hard spherical particles. The volume of the effective hard particle reflects both steric and electrostatic repulsion and thus varies with pH and ionic strength. The pH dependence of the effective volume is shown to agree well with that previously obtained from analysis of the concentration dependence of sedimentation equilibrium and static light scattering. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 3466-3469, 2007
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Allen P. Minton,