Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487657 | Journal of Pharmaceutical Sciences | 2007 | 8 Pages |
Abstract
Progesterone rapidly dissolves in an aqueous solution containing hydroxypropylâβâcyclodextrin (HPBCD) at 1:2 molar ratio, forming a soluble inclusion complex. After filtration and freezeâdrying of the final solution, the final powder was examined by SEM, DSC, TGA, XRD, Raman, and FTIR spectroscopy. Experimental results confirm that an inclusion complex exists in the solid state and possible structure of the complex is briefly discussed. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 1729-1736, 2007
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Authors
Giorgio Zoppetti, Nadia Puppini, Francesca Ospitali, Adamo Fini,