Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487663 | Journal of Pharmaceutical Sciences | 2007 | 19 Pages |
Abstract
This study used in situ spectroscopy to reveal the multiple solidâstate forms that appear during isothermal dehydration. Hydrate forms of piroxicam and carbamazepine (CBZ) were investigated on hotâstage at different temperatures using nearâinfrared (NIR) and Raman spectroscopy combined with multivariate modeling. Variable temperature Xâray powder diffraction, differential scanning calorimetry, thermogravimetric analysis, and Karl Fisher titrimetry were used as reference methods. Partial least squares discriminant analysis (PLSâDA) was performed to qualitatively evaluate the phase transition. It was shown that the constructed PLSâDA models, where spectral differences were directly correlated to solidâstate modifications, enabled differentiation between the multiple forms. Qualitative analysis revealed that during dehydration, hydrates, such as CBZ dihydrate, may go through several solidâstate forms, which must be considered in quantitative model construction. This study demonstrates that in situ analysis can be used to monitor the dehydration and reveal associated solidâstate forms prior to quantification. The utility of the complementary spectroscopic techniques, NIR and Raman, have been shown. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 1802-1820, 2007
Keywords
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Authors
Karin Kogermann, Jaakko Aaltonen, Clare J. Strachan, Kati Pöllänen, Peep Veski, Jyrki Heinämäki, Jouko Yliruusi, Jukka Rantanen,