| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2487694 | Journal of Pharmaceutical Sciences | 2007 | 11 Pages |
Abstract
ABSTRACTThe crystal structures of γ-carbamazepine (P 1¯, Z′ = 4) and chlorothiazide N,N-dimethylformamide solvate (1/2) (P21/c, Z′ = 2) have been determined from synchrotron and laboratory X-ray powder diffraction data, respectively, using simulated annealing. Both structures represent a significant challenge for global optimization and the successful solutions and subsequent refinements highlight the ever-expanding range of applicability of powder diffraction to structural problems of pharmaceutical relevance.
Keywords
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Authors
Philippe Fernandes, Kenneth Shankland, Alastair J. Florence, Norman Shankland, Andrea Johnston,