Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2487864 | Journal of Pharmaceutical Sciences | 2009 | 5 Pages |
Abstract
The influence of compression force to inner core tablet or to outer coating layer of the compressionâcoated tablet on the function of timeâcontrolled disintegration was investigated. The inner core tablet was directly compacted by sodium diclofenac (model drug) and ethylcellulose (EC) with 4.6âμm particle size was used as an outer coating layer. The immersion time of the compressionâcoated tablet previously soaked in pH 1.2 solution to simulate the residence time of the tablet in the GI tract affecting the dissolution behavior of the compressionâcoated tablet was also investigated. The effect of the amount of the outer coating layer used on the drug release was examined. The results indicate that sodium diclofenac released from these compressionâcoated tablets exhibited a longer lag of a period about 16.3 h in both distilled water and pH 6.8 buffer solution, followed by a different drug release behavior. The lag time was independent of the pH of dissolution medium, and the immersion time in pH 1.2 solution. After that lag time, the outer shell of the compressionâcoated tablets broke into two halves to make a rapid drug release. However, the drug release behavior of the soaked tablet in pH 6.8 buffer solution was dependent on the immersion time. The compression force <â200 kg/cm2 to the inner core tablet influenced the release behavior of drug less, but >â200 kg/cm2 might delay the lag time. The lag time of the compressionâcoated tablets was linearly correlated with the compression force to the outer coating layer (râ=â0.9896). We also found that the more the amount of outer coating layer added, the longer the lag time obtained. The study demonstrates that the timeâcontrolled disintegration of the compressionâcoated tablet was effectively controlled by the compression force applied and the amount of outer coating layer added. © 2001 WileyâLiss, Inc. and the American Pharmaceutical Association J Pharm Sci 90:2005-2009, 2001
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
KungâHsu Lin, ShanâYang Lin, MeiâJane Li,