Synthesis of Some New Isoxazoline Derivatives of Chalconised Indoline 2-one as a Potential Analgesic, Antibacterial and Anthelmimtic Agents

Aseries of novel 1[5"-(2"'-substituted phenyl)-4",5"'-dihydro isoxazole-3"-yl]-3-[(4 substituted phenyl)imino]1- 3-dihydro-2H-indole-2-one were synthesized from different substituted chalconised indole-2,3-dione was prepared fromthe different chalconised Isatin. The structures ofthe Compounds were elucidated by elemental and spectral (IR, 1H NMR, and MS) analysis. The synthesized Compounds were screened fortheir analgesic activity by the acetic acid induced Writhing method and in vitro antimicrobial activity against the Gram-positive bacteria-Staphylococcus aureus and the Gram-negative bacteria-Pseudomonas auroginosa, Pseudomonas mirabilis, and E. coli by the cup plate agar diffusion method. Compounds 6a1, 6a3, 6b3, and 6b2 were found to be active against bacteria. The Compounds 6a1, 6b3, and 6a3 show a significant analgesic activity. Synthesized Compounds also screened for anthelmintic activity against Pheretima posthuma. Compounds 6a1, 6b1, and 6b3 show significant anthelmintic activity.