| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2498369 | Asian Journal of Pharmaceutical Sciences | 2016 | 9 Pages |
Abstract
The number of particulate delivery systems for biologics is negligible compared to liquid dosage forms, signifying the complications associated with development of solid protein delivery systems. Particulate protein delivery systems can improve stability, reduce viscosity of suspensions at high protein concentration and allow for controlled drug release. This review discusses current advances in controlled delivery of particulate protein formulations. While the focus lies on protein crystals and delivery systems employing protein crystals, amorphous protein particles will also be addressed. Crystallization and precipitations methods and modifications allowing controlled delivery with and without encapsulation are summarized and discussed.
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmaceutical Science
Authors
Sebastian Puhl, Lorenz Meinel, Oliver Germershaus,