| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2498471 | Asian Journal of Pharmaceutical Sciences | 2015 | 7 Pages |
Abstract
This work evaluates intercalation of Nortriptyline (NT) and Venlafaxine (VFX) in an interlayer gallery of Na+-MMT (Montmorillonite), which was further compounded with Poly (L-Lactide) (PLLA) to form microcomposite spheres (MPs) for oral controlled drug delivery. The XRD patterns, thermal and spectroscopic analyses indicated intercalation of drugs into the MMT interlayer that was stabilized by electrostatic interaction. No significant changes in structural and functional properties of drugs were found in the MMT layers. In vitro drug release studies showed controlled release pattern.
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Authors
Shalini Rajkumar, Bhavesh D. Kevadiya, Hari C. Bajaj,