Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2499927 | Farmacéuticos de Atención Primaria | 2012 | 8 Pages |
Abstract
It shows a critical review of meta-analysis assessing the efficacy of statins in primary prevention of cardiovascular disease. We searched MEDLINE, EMBASE and Cochrane (period: January 2000 to December 2011) for meta-analysis of randomized trials conducted to study the effect of statins in primary prevention of cardiovascular disease. We used PRISMA statement to evaluate accuracy and reliability of meta-analysis. We selected 9 meta-analysis (mean of patients: 88.006). Five studies found a benefit in mayor cardiovascular events (range of relative risk [RR]: 0.69-0.85). Seven meta-analysis obtained improvement in mayor coronary events (range of RR: 0.61-0.77). There was no agreement between the results of total mortality, coronary mortality and cerebrovascular events. This critical review of meta-analysis suggests a modest benefit of statins in a primary prevention set-up.
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Authors
M.C. Montero-Balosa, R. Fernández-Urrusuno, J.R. Boxó-Cifuentes,