Article ID Journal Published Year Pages File Type
2500721 Future Journal of Pharmaceutical Sciences 2016 8 Pages PDF
Abstract

Furopyrimidines are fused heterocyclic ring systems. Structurally, they are bioisoteres to purines and exerting pharmacological actions in various aspects. They are known to play an important role in different disease conditions. Furo[2,3-d]pyrimidines derivatives have been explored for their inhibitory activity against different protein kinase enzymes. The present review, to the best of our knowledge, is the first compilation on synthesis, anticancer activity, via inhibition of various protein kinase enzymes, and structure–activity relationships of furo[2,3-d]pyrimidines derivatives reported to date.

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