Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2500729 | Future Journal of Pharmaceutical Sciences | 2015 | 7 Pages |
Abstract
BackgroundMolybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases.MethodsTwenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity toward molybdenum hydroxylases.Results and conclusionThe tested quinazolines inhibited both xanthine oxidase and aldehyde oxidase enzymes in a competitive pattern with Ki values range of 66–753 μM. Pharmacophore prediction methodology was used to study the structure requirements of those inhibitors.
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Authors
Hussein I. El-Subbagh, Alaa A.-M. Abdel-Aziz, Mohamed A. Al-Omar, Fatmah A. Al-Omary,