Article ID Journal Published Year Pages File Type
2500895 International Journal of Pharmaceutics 2016 4 Pages PDF
Abstract

The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 407-based formulations with 1 % active ingredient indicated complete growth inhibition of the dermatophyte fungus Trichophyton rubrum after 6 days of incubation.

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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmaceutical Science
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