Nanosuspensions of poorly water-soluble drugs prepared by bottom-up technologies

In recent years, nanosuspension has been considered effective in the delivery of water-soluble drugs. One of the main challenges to effective drug delivery is designing an appropriate nanosuspension preparation approach with low energy input and erosion contamination, such as the bottom-up method. This review focuses on bottom-up technologies for preparation of nanosuspensions. The features and advantages of drug nanosuspension, including bottom-up methods as well as the corresponding characterization techniques, solidification methods, and drug delivery dosage forms, are discussed in detail. Certain limitations of commercial nanosuspension products are also reviewed.

Graphical abstractNanosuspension could be prepared by precipitation–ultrasonication method. Anti-solvent precipitation is an effect way to make nano-sized particles; ultrasonication could control the process of nucleation and crystallization effectively. Spray drying or freeze drying could make dry nanoparticles that could store a longer time.Figure optionsDownload full-size imageDownload high-quality image (171 K)Download as PowerPoint slide