| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2501261 | International Journal of Pharmaceutics | 2015 | 5 Pages |
Abstract
The effect of salt formulation on the electrostatic property of active pharmaceutical ingredients was investigated. The electrostatic property of weak acids (carboxylic acids and amide-enole type acid) and their sodium salts was evaluated by a suction-type Faraday cage meter. Free carboxylic acids showed negative chargeability, whereas their sodium salts showed more positive chargeability than the free acids. However, no such trend was observed for amide-enole type acids.
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Pharmacology, Toxicology and Pharmaceutical Science
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Authors
Kenta Fujinuma, Yuji Ishii, Yasuo Yashihashi, Estuo Yonemochi, Kiyohiko Sugano, Katsuhide Tarada,