| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2502174 | International Journal of Pharmaceutics | 2013 | 5 Pages |
The purpose of the research was to introduce a procedure to derive a powder compression parameter (EM A) representing particle yield stress using an effective medium equation and to compare the EM A parameter with the Heckel compression parameter (1/K).16 pharmaceutical powders, including drugs and excipients, were compressed in a materials testing instrument and powder compression profiles were derived using the EM and Heckel equations. The compression profiles thus obtained could be sub-divided into regions among which one region was approximately linear and from this region, the compression parameters EM A and 1/K were calculated.A linear relationship between the EM A parameter and the 1/K parameter was obtained with a strong correlation. The slope of the plot was close to 1 (0.84) and the intercept of the plot was small in comparison to the range of parameter values obtained. The relationship between the theoretical EM A parameter and the 1/K parameter supports the interpretation of the empirical Heckel parameter as being a measure of yield stress. It is concluded that the combination of Heckel and EM equations represents a suitable procedure to derive a value of particle plasticity from powder compression data.
Graphical abstractA correlation between the effective medium equation's A parameter and the Heckel equation's 1/K parameter. Error bars are standard deviations.Figure optionsDownload full-size imageDownload high-quality image (66 K)Download as PowerPoint slide
