| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2502882 | International Journal of Pharmaceutics | 2012 | 7 Pages |
Abstract
The anti-depressant pharmaceutical tianeptine has been investigated to determine the dynamics of polymorph formation under various pH conditions. By varying the pH two crystalline polymorphs were isolated. The molecular and crystal structures have been determined to identify the two polymorphs. One polymorph is an amino carboxylic acid and the other polymorph is a zwitterion. In the solid state the tianeptine moieties are bonded through hydrogen bonds. The zwitterion was found to be less stable and transformed to the acid form. During this investigation an amorphous form was identified.
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Pharmacology, Toxicology and Pharmaceutical Science
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Authors
Liana Orola, Mikelis V. Veidis, Inese Sarcevica, Andris Actins, Sergey Belyakov, Aleksandrs Platonenko,