Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2502888 | International Journal of Pharmaceutics | 2012 | 6 Pages |
Abstract
In this work, we focused on mesoporous silica nanoparticles (MSN) for one photon excitated photodynamic therapy (OPE-PDT) combined with drug delivery and carbohydrate targeting applied on retinoblastoma, a rare disease of childhood. We demonstrate that bitherapy (camptothecin delivery and photodynamic therapy) performed with MSN on retinoblastoma cancer cells was efficient in inducing cancer cell death. Alternatively MSN designed for two-photon excited photodynamic therapy (TPE-PDT) were also studied and irradiation at low fluence efficiently killed retinoblastoma cancer cells.
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Pharmacology, Toxicology and Pharmaceutical Science
Pharmaceutical Science
Authors
Magali Gary-Bobo, Youssef Mir, Cédric Rouxel, David Brevet, Ouahiba Hocine, Marie Maynadier, Audrey Gallud, Afitz Da Silva, Olivier Mongin, Mireille Blanchard-Desce, Sébastien Richeter, Bernard Loock, Philippe Maillard, Alain Morère, Marcel Garcia,