Article ID Journal Published Year Pages File Type
2503224 International Journal of Pharmaceutics 2011 7 Pages PDF
Abstract

A solid dispersion (SD) powder of indomethacin (IM) with crospovidone (CrosPVP) shows useful characteristics for manufacturing dosage forms. Four types of commercial CroPVP, Polyplasdone® XL (XL) used as the initial carrier, Polyplasdone® XL10 and INF-10® manufactured by milling XL, and Kollidon® CL (CL) marketed by another company, were compared. The limit of the IM–CrosPVP weight ratio with which an SD can be prepared (maximum IM content) was calculated on the basis of the heat of fusion of physical mixtures of IM and CrosPVP with various weight ratios. When Polyplasdone®s were used, the maximum IM content increased with the specific surface area of the CrosPVP. When CL was used, however, it was about half of that obtained with XL, even though the difference between XL and CL was not observed in the physicochemical characteristics (particle size, specific surface area, flowability, glass transition temperature, IR spectra, and solid state NMR spectra). As determined by pore size distribution measurement, the volume of pore of which size is larger than the particle size of IM was less in CL than in XL. Therefore, the effective surface area of CrosPVP that comes in contact with IM is important for the preparation of the SD.

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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmaceutical Science
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