Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2503250 | International Journal of Pharmaceutics | 2011 | 14 Pages |
In this article, the use of mid-IR in pharmaceutical settings is reviewed. An overview of mid-IR instrumentation and sampling techniques is provided. Subsequently, different pharmaceutical applications of the technique are described, including structure elucidation and identification, characterization of crystalline (polymorphs, hydrates, salts and co-crystals) and amorphous forms, as well as quantitative and remote sensing applications. Finally, an overview of current trends in FTIR-based imaging applications is provided, with special attention paid to currently emerging FTIR–AFM coupled techniques which have high spatial resolution.
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