Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2503309 | International Journal of Pharmaceutics | 2011 | 7 Pages |
This work introduces a novel route to the sodium carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug, 5-fluorouracil (5-Fu). The results show that 5-Fu is successfully incorporated into the biocompatible polymer, sodium carboxymethylcellulose (NaCMC)-based fibers with good stability, desired drug loading content and 100% entrapment efficiency. Furthermore, the drug release rate of the as-prepared drug-loaded fibers could be well controlled. The drug release behavior of the 5-Fu-loaded NaCMC fibers shows a diffusion mechanism, obeying Ritger–Peppas kinetics model. The drug release behavior of the as-prepared products demonstrates their promising application in drug delivery system.
Graphical abstractOn the carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug for the use in drug delivery system.Figure optionsDownload full-size imageDownload as PowerPoint slide