Article ID Journal Published Year Pages File Type
2503921 International Journal of Pharmaceutics 2010 11 Pages PDF
Abstract

The crystal structure of a monohydrate of (±)-mefloquinium chloride, (±)-[MEFHCl·(H2O)], has been obtained from data collected at 120 K. Further details of the crystal structure of a hemihydrate, (±)-[MEFHCl·½(H2O)], previously determined at room temperature, are also reported from data collected at 120 K. The structural data, along with X-ray powder patterns, infrared spectra (both mid and near IR ranges) and DSC data, provide definitive evidence for the two hydrates. Further attempts to completely resolve the crystal structure of a tetragonal solvated phase failed due to the considerable disorder, involving the solvates, either water or methanol, even at 120 K, however X-ray powder pattern and infrared spectral and DSC data for this phase are also reported. Comparisons of the data obtained for the hydrates in this study, with X-ray powder patterns and mid-infrared spectra of previously reported forms of (±)-mefloquinium chloride have highlighted erroneous assignments and allowed structural identification of previously and differently designated forms.

Graphical abstractCrystal structures, X-ray powder patterns, infrared spectra and DSC data of three solvates of erythro-(±)-mefloquinium chloride are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

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