| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2504202 | International Journal of Pharmaceutics | 2010 | 9 Pages |
Abstract
An experimental investigation of extrusion–spheronisation (E–S) of a novel microcrystalline cellulose (MCC) formulation, comprising dimethyl sulfoxide (DMSO) as the granulating liquid, is reported. The extrusion–spheronisation performance of DMSO/MCC pastes is compared to that of similar water/MCC formulations and their rheological behaviours similarly assessed using lubricated squeeze flow. A case study involving water, DMSO and anhydrous ethanol yields important information regarding the physico-chemical properties necessary for solvents to be suitable for the extrusion of MCC.
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Authors
S. Mascia, C. Seiler, S. Fitzpatrick, D.I. Wilson,