Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2504238 | International Journal of Pharmaceutics | 2010 | 8 Pages |
Abstract
Topical therapy is highly desirable in treating nail disorders due to its localized effects, which results in minimal adverse systemic events and possibly improved adherence. However, the effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Current research on nail permeation that focuses on altering the nail plate barrier by means of chemical treatments, penetration enhancers as well as physical and mechanical methods is reviewed. A new method of nail sampling is examined. Finally limitations of current ungual drug permeability studies are briefly discussed.
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmaceutical Science
Authors
Rania Elkeeb, Ali AliKhan, Laila Elkeeb, Xiaoying Hui, Howard I. Maibach,